Effect of Stevioside in Postpandrial Glucose in Healthy Adults
Status:
Withdrawn
Trial end date:
2013-09-01
Target enrollment:
Participant gender:
Summary
A natural sweetener (Stevia Rebaudina Bertoni) reduces blood glucose levels and blood
pressure according to various preclinical and clinical studies conducted worldwide. Since it
is not found many studies in the literature wich compares Stevia Rebaudiana with saccharin,
we've proposed a randomized crossover clinical trial comparing the effects on postprandial
capillary blood glucose and blood pressure in healthy adults.
Sample: healthy professionals from two health centers in Alava (Kakuabizkarra primary care
center and Txagorritxu hospital). Inclusion criteria: Professionals of two health centers of
Álava (Lakuabizkarra and Txagorritxu) and active employment status at the beginning of the
trial, weighing more than 50kg and age over 18 years.
Intervention: 200mg capsules of Stevia or 250mgcapsules of saccharin. Measurements: Capillary
blood glucose and blood pressure, fasting and after eating. Evaluation of satiety, hunger and
fullness by questionnaire after intake, and at the end of the day.
Statistical analysis: Compare the postprandial capillary glucose levels between 8 am and 1 st
hour, 2nd hour 3rd hour after intake between treatments by ANCOVA. We will also compare blood
pressure before and after intake between treatments. We will also compare by t test or paired
Wilcoxom (depending on the nature of the variable) the results of the questionnaire after
intake between treatments.