Effect of Stomach Reduction Surgery on the Parameters of Amoxicillin
Status:
Completed
Trial end date:
2017-04-03
Target enrollment:
Participant gender:
Summary
The objective of this study was to evaluate the impact of bariatric surgery on the
pharmacokinetics of amoxicillin.
Methods: This study was performed as a randomized, open-label, single-dose clinical trial,
with two periods of treatment, in which obese subjects (n=8) received amoxicillin 500 mg
capsule orally before and 2 months after the Roux-en-Y gastric bypass surgery. The
amoxicillin plasma concentration was determined by liquid chromatography coupled to mass
spectrometry (LC-MS/MS).
Phase:
N/A
Details
Lead Sponsor:
Nucleo De Pesquisa E Desenvolvimento De Medicamentos Da Universidade Federal Do Ceara