Effect of Subanesthetic Dose of Esketamine on Sleep Quality and Recovery of Gastrointestinal Function in Patients Undergoing General Anesthesia Laparoscopic Uterine Surgery in the Early Postoperative Period

• Status: Recruiting
• Trial end date: 2023-06-30
• Target enrollment: 0
• Participant gender: Female

Summary

Patients undergoing gynecological surgery are at high risk of developing postoperative sleep disorders. Intraoperative opioid use is detrimental to the patient's postoperative recovery of gastrointestinal function. Esketamine has sedative, hypnotic, analgesic, inflammatory response suppression, and antidepressant effects. Its hypnotic mechanism may be related to its rapid blockade of NMDA receptors and hyperpolarization-activated cyclic nucleotide-gated cation channels. Also can reduce the application of perioperative opioids, which in turn promotes the recovery of gastrointestinal function in patients after surgery.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Zhuan Zhang
• Treatments: Esketamine

Criteria

Inclusion Criteria:

1. Age ≥ 40 years;

2. ASA class I-III;

3. Proposed laparoscopic total hysterectomy/myomectomy;

4. Operative time ≥ 1 h.

Exclusion Criteria:

• patient refusal;

1. known allergy to anesthetic drugs;

2. chronic use of opioids or sedative-hypnotic drugs;

3. history of psychiatric or neurological disease;

4. previous or planned neurosurgical procedures;

5. hearing or visual impairment that precludes a scale assessment.