Effect of Subanesthetic Dose of Ketamine Combined With Propofol on Cognitive Function in Depressive Patients Undergoing Electroconvulsive Therapy

• Status: Unknown status
• Trial end date: 2017-02-01
• Target enrollment: 0
• Participant gender: All

Summary

Electroconvulsive therapy (ECT) is an effective treatment for depression compared with the current antidepressant agents，but the most important side effect is cognitive dysfunction. The purpose of this study is to determine whether subanesthetic dose of ketamine combined with propofol is superior to propofol anesthesia alone in improving cognitive function in depressive patients undergoing ECT.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: First Affiliated Hospital of Chongqing Medical University
• Treatments: Ketamine; Propofol

Criteria

Inclusion Criteria:

1. diagnosed with moderate or severe depression according to Diagnostic and Statistical Manual of Mental Disorders

2. aged from 18 to 65 years old

Exclusion Criteria:

1. cerebrovascular malformation, arterial aneurysm, hypertension, or glaucoma;

2. classification of American Society of Anesthesiologists physical status score IV or V;

3. complications such as respiratory disease, cardiovascular disease, intracranial hypertension, cerebral vascular disorder;

4. presence of a foreign body such as pacemaker, intracranial electrode, and clips;

5. history of seizures;

6. history of drug abuse;

7. concomitant presence of a mental disorder;

8. pregnancy;

9. history of serious adverse effects related to anesthetics;

10. refusal to consent for the study, or refusal to undergo one single ECT during the first week of therapy.

11. hyperthyreosis