Effect of Systemic Ropivacaine on Hyperalgesia, Flare Reaction and Peripheral Nerve Excitability

• Status: Completed
• Trial end date: 2011-07-01
• Target enrollment: 0
• Participant gender: Male

Summary

The purpose of this study is to compare the effect of intravenous ropivacaine and lidocaine on the receptive field of primary sensory afferents and their influence on the vascular bed.

*Trial with medicinal product

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Zurich
• Treatments: Ropivacaine

Criteria

Inclusion criteria:

1. Male

2. Age: 18 - 65 years

3. Weight: 50-100kg

4. Height: 155-195cm

5. Signed and dated informed consent

6. Sufficient command of German language

Exclusion criteria:

1. Contraindications to the class of drugs under study

2. Vulnerable subjects (intellectually or mental impaired)

3. Known hypersensitivity to class of drugs or the investigational product

4. Drug abuse

5. Known peripheral neuropathies

6. Diabetes mellitus

7. Chronic alcohol consumption

8. Congestive heart disease

9. Participants of other studies during study period

10. Smoker