Effect of Tadalafil Administration on Vasodilatation Mediated by Flow in Patients With Obesity Grade I-II
Status:
Unknown status
Trial end date:
2019-09-01
Target enrollment:
Participant gender:
Summary
Obesity is a public health problem, not only for its high prevalence, but also because of the
comorbidities found in it. Within the physiopathological mechanisms associated with obesity
is a low-grade inflammatory state that is associated with endothelial dysfunction Endothelial
dysfunction is known to be the beginning of the atherosclerotic process that eventually leads
to the development of cardiovascular disease.
Erectile dysfunction is an example of endothelial dysfunction, where blood flow is
compromised as a consequence of a reduction in the production of nitric oxide among others.
Tadalafil, which is an inhibitor of PDE-5, is currently used as a treatment for erectile
dysfunction. However, it has been observed that the administration of tadalafil in patients
with éndothelial dysfunction decreases arterial stiffness, having a positive effect on it, in
addition it reduces the pulse pressure, systolic and diastolic pressure.
Phase:
Phase 3
Details
Lead Sponsor:
Centro Universitario de Ciencias de la Salud, Mexico