Effect of Tadalafil on Insulin Secretion and Insulin Sensitivity in Obese Men.

• Status: Completed
• Trial end date: 2015-11-01
• Target enrollment: 0
• Participant gender: Male

Summary

Obesity is a chronic disease of multifactorial etiology that develops from the interaction of the influence of nutritive , metabolic , cellular and molecular psychological factors.

Tadalafil is Is a drug inhibiting the enzyme phosphodiesterase-5 (PDE-5), responsible for inactivating the vasodilator nitric oxide. USING paragraph was mainly treat erectile dysfunction, and recently approved for the treatment of pulmonary hypertension , it is innovative because of its longer life means, provides efficacy after 36 hours and the highest selectivity.

The aim of this study is to evaluate the effect of tadalafil on insulin sensitivity and insulin secretion in obese men.

The investigators hypothesis is that the administration of tadalafil improve the insulin sensitivity and insulin secretion in obese men.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Guadalajara
• Treatments: Insulin; Insulin, Globin Zinc; Magnesium Oxide; Tadalafil

Criteria

Inclusion Criteria:

• Men

• Age: 30-50 years

• BMI: 30 to 39.9 kg/m²

• No Pharmacotherapy during the last 3 months

• Signature Consent under Information

Exclusion Criteria:

• Cholesterol: ≥ 240 mg / dl

• Triglycerides: ≥ 400 mg / dl

• Fasting glucose: ≥ 126 mg / dl

• Diabetes mellitus.

• Hypertension

• Patients with renal, liver and / or thyroid disease

• Consumption of drugs with known effects on glucose or insulin metabolism.

• Use of cigar and / or drugs

• Hypersensitivity to tadalafil