Effect of Tadalafil on Insulin Secretion and Insulin Sensitivity in Obese Men.
Status:
Completed
Trial end date:
2015-11-01
Target enrollment:
Participant gender:
Summary
Obesity is a chronic disease of multifactorial etiology that develops from the interaction of
the influence of nutritive , metabolic , cellular and molecular psychological factors.
Tadalafil is Is a drug inhibiting the enzyme phosphodiesterase-5 (PDE-5), responsible for
inactivating the vasodilator nitric oxide. USING paragraph was mainly treat erectile
dysfunction, and recently approved for the treatment of pulmonary hypertension , it is
innovative because of its longer life means, provides efficacy after 36 hours and the highest
selectivity.
The aim of this study is to evaluate the effect of tadalafil on insulin sensitivity and
insulin secretion in obese men.
The investigators hypothesis is that the administration of tadalafil improve the insulin
sensitivity and insulin secretion in obese men.