Effect of Taurine on Glycemic, Lipid and Inflammatory Profile in Individuals With Type 2 Diabetes
Status:
Not yet recruiting
Trial end date:
2023-04-01
Target enrollment:
Participant gender:
Summary
Type 2 diabetes mellitus (DM2) is characterized by chronic hyperglycemia, which is a risk
factor for comorbidities and death. Although conventional pharmacotherapy is effective, some
individuals do not reach the glycemic targets, requiring adjuvant therapies. Taurine is a
semi-essential amino acid with antioxidant and osmoregulatory properties, commonly used as a
nutritional supplement. Pre-clinical studies show its effectiveness in reducing blood glucose
and cholesterol, but there are no well-conducted clinical studies evaluating the effect of
taurine on glycated hemoglobin. Additionally, animal models showed that taurine had a
protective effect from diabetic nephropathy. The hypothesize of this study is that taurine
administration improves the glycemic, lipid, inflammatory, and anthropometric parameters in
DM2 individuals.