Effect of Thiamine on Oxygen Utilization (VO2) in Critical Illness

• Status: Completed
• Trial end date: 2012-10-01
• Target enrollment: 0
• Participant gender: All

Summary

The objective of this study is to determine the effect of thiamine therapy on oxygen consumption in critically-ill patients. The investigators will evaluate this by measuring VO2 before and after thiamine administration in patients admitted to the ICU and requiring mechanical ventilation.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Beth Israel Deaconess Medical Center
• Collaborator: American Medical Association
• Treatments: Thiamine

Criteria

Inclusion Criteria:

• Adult patients (age > 18 years) admitted to an ICU

• Mechanically ventilated

Exclusion Criteria:

• Unstable ventilator settings during measurement of VO2

• Temp > 100 at time of VO2 measurement

• FIO2 > 60%

• Endotracheal cuff leak, chest tube, or other evident source of air leak

• Thiamine supplementation within 24 hours prior to study enrollment