Effect of Thiamine on Serum Glucagon And Reactive Oxygen Species (ROS)

• Status: Completed
• Trial end date: 2022-12-01
• Target enrollment: 0
• Participant gender: All

Summary

This research is a clinical trial with a Randomized Controlled Trial (RCT) design. The purpose is to identify the effect of intravenous thiamine administration compared to normal saline placebo on glucagon levels and ROS levels in patients undergoing general anesthesia surgery

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Universitas Sumatera Utara
• Treatments: Thiamine

Criteria

Inclusion Criteria:

• Patients aged 18-65 years who undergo surgery under general anesthesia

• ASA physical statuses 1 and 2

• Sepsis

Exclusion Criteria:

• Refuse to participate

• Diabetes mellitus, experience shock sepsis or lactic acidosis

• Have a history of hypersensitivity (allergy) to thiamine

• Thiamine deficiency

• Take immunomodulatory drugs, antiplatelet or anticoagulants surgery duration > 6 hours, and thiamin regularly

• They experience massive bleeding and receive blood transfusions preoperatively, intraoperatively, or postoperatively