Overview
Effect of Three Weight-adjusted Vasopressors for Elective Cesarean Delivery
Status:
Not yet recruiting
Not yet recruiting
Trial end date:
2022-11-20
2022-11-20
Target enrollment:
0
0
Participant gender:
Female
Female
Summary
This study compared the effects of prophylactic infusion of metaraminol, phenylephrine and norepinephrine adjusted according to body weight on fetal acid-base balance and maternal hemodynamics.Phase:
Phase 4Accepts Healthy Volunteers?
Accepts Healthy VolunteersDetails
Lead Sponsor:
Xuzhou Medical UniversityTreatments:
Metaraminol
Norepinephrine
Oxymetazoline
Phenylephrine
Criteria
Inclusion Criteria:1. Singleton pregnancy at term scheduled to be delivered via elective cesarean delivery;
2. height 150-180 cm;
3. American Society of Anesthesiologists (ASA) physical status II-III;
4. body mass index (BMI) <35 kg/m2.
Exclusion Criteria:
1. transverse presentation, fetal macrosomia;
2. uterine abnormalities (eg, large fibroids, bicornuate uterus);
3. polyhydramnios;
4. ruptured membranes, oligohydramnios;
5. intrauterine growth restriction;
6. gestational or nongestational hypertension, diabetes, or eclampsia;
7. hypertensive disorders or any condition associated with autonomic neuropathy (such as
diabetes mellitus for >10 years) or renal failure;
8. contraindications for combined spinal-epidural anesthesia;
9. participants who declined to sign informed consent forms.