Effect of Ticagrelor Versus Clopidogrel on Endothelial Dysfunction and Vascular Inflammation
Status:
Unknown status
Trial end date:
2017-03-01
Target enrollment:
Participant gender:
Summary
The purpose of this study is to compare the effects of ticagrelor and clopidogrel on
endothelial dysfunction and vascular inflammation
Ticagrelor will lead to beneficial pleiotropic effects compared with treatment with
clopidogrel in patients receiving a drug-eluting stents (DES) during percutaneous coronary
intervention (PCI) for non-ST-segment acute coronary syndrome (NSTE-ACS) beyond 1 month after
the index event. Ticagrelor treatment will improve percent flow-mediated dilation (FMD)
values and reduces inflammatory gene expression on peripheral blood mononuclear cells.