Effect of Ticagrelor vs. Dipyridamole on Adenosine Uptake

• Status: Completed
• Trial end date: 2017-01-01
• Target enrollment: 0
• Participant gender: All

Summary

The investigators are trying to determine if a single dose of Ticagrelor will increase delivery of intraarterially-infused adenosine into the forearm interstitium, consistent with adenosine reuptake blockade.

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Vanderbilt University
• Treatments: Adenosine; Dipyridamole; Ticagrelor

Criteria

Inclusion Criteria:

1. Subjects will be healthy volunteers, without significant pulmonary, cardiovascular gastrointestinal, hematological or renal diseases

2. Not taking any regular medications

3. Able to provide signed consent prior to study participation.

Exclusion Criteria:

1. History of asthma

2. Pregnancy

3. Exposure to an investigational drug in the last 2 months.

4. Known hypersensitivity to study medications