Effect of Topical Dexamethasone on Histologic Response of Human Dental Pulp
Status:
Completed
Trial end date:
2013-12-01
Target enrollment:
Participant gender:
Summary
Abstract Aim The aim of this randomized clinical trial was to histologically investigate
possible effects of dexamethasone application on pulp tissue healing during one step mineral
trioxide aggregate (MTA)-direct pulp capping (DPC) and miniature pulpotomy (MP) in healthy
human premolar teeth.
Methodology Forty intact premolar teeth of 10 orthodontic patients, scheduled for extraction,
were randomized for DPC (n=20) or MP (n=20). A high speed bur under copious water coolant was
used for mechanical exposing of buccal pulp horn site. Prior to sealing with white ProRoot
MTA, 10 out of twenty pulpal wounds of each group were randomly received dexamethasone.
Cavities were restored with glass ionomer. Teeth vitality was evaluated in 7, 21, 42, and 60
day follow-ups. Signs and/or symptoms of irreversible pulpitis or pulp necrosis were
considered as failure. After 60 days, the teeth were extracted and submitted for histological
examination. Kruskal-Wallis and Fisher exact tests were used for statistical analysis of the
data (P=0.05).
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