Effect of Topical Melatonin Application on Dental Implant Osseointegration and Marginal Bone Level

• Status: Recruiting
• Trial end date: 2020-11-01
• Target enrollment: 0
• Participant gender: All

Summary

Background: Melatonin (N-acetyl-5-methoxy-tryptamine) is an indoleamine synthesized and secreted by the pineal gland and other organs, such as the retina, bone marrow, and intestines in a circadian pattern. Some authors claimed that Melatonin induces bone formation, increase bone density, and bone implant contact. According to animal and human studies the melatonin can be used topically during implant placement to increase bone implant contact and reduce marginal bone loss.

Purpose: The aim of this study was to evaluate the effect of the topical administration of melatonin on osseointegration of dental implants and in minimize marginal bone loss.

Materials and Methods: Twenty single-piece endosseous implants (Dentium Co, Korea) will use to restore missing lower teeth from canine to first molar area. The study will be split-mouth technique, each patient serve as his own control (served into 2 groups), the study side (topical application of melatonin in the implant side), and the control side (no melatonin in the other implant side of the same patients).The primary and secondary stability of dental implant will be evaluated by periotest M device and measure bone level as baseline immediately after implant placement and after 6 months follow up by CBCT.

• Phase: Phase 3
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Baghdad
• Treatments: Melatonin

Criteria

Inclusion Criteria:

1. Patients have good oral hygiene.

2. Patients were periodontally healthy.

3. Patients had at least two missing teeth in the upper or lower jaw (canine to 1st molar area) indicated for the dental implant.

Exclusion Criteria:

1. Patients with any systemic diseases that influence bone healing such as osteoporosis and diabetes mellitus.

2. Fully edentulous.

3. Patients who had parafunctional habits.

4. Smokers.

5. Patients who were not able to follow the treatment protocol.

-