Effect of Topical Melatonin Application on Dental Implant Osseointegration and Marginal Bone Level
Status:
Recruiting
Trial end date:
2020-11-01
Target enrollment:
Participant gender:
Summary
Background: Melatonin (N-acetyl-5-methoxy-tryptamine) is an indoleamine synthesized and
secreted by the pineal gland and other organs, such as the retina, bone marrow, and
intestines in a circadian pattern. Some authors claimed that Melatonin induces bone
formation, increase bone density, and bone implant contact. According to animal and human
studies the melatonin can be used topically during implant placement to increase bone implant
contact and reduce marginal bone loss.
Purpose: The aim of this study was to evaluate the effect of the topical administration of
melatonin on osseointegration of dental implants and in minimize marginal bone loss.
Materials and Methods: Twenty single-piece endosseous implants (Dentium Co, Korea) will use
to restore missing lower teeth from canine to first molar area. The study will be split-mouth
technique, each patient serve as his own control (served into 2 groups), the study side
(topical application of melatonin in the implant side), and the control side (no melatonin in
the other implant side of the same patients).The primary and secondary stability of dental
implant will be evaluated by periotest M device and measure bone level as baseline
immediately after implant placement and after 6 months follow up by CBCT.