Effect of Tramadol in Prevention of Postpartum Depression
Status:
Completed
Trial end date:
2019-08-13
Target enrollment:
Participant gender:
Summary
The incidence of postpartum depression in Europe and the United States is about 10%, while in
China the incidence rate of 15.7-39.8%. Postpartum depression is one of the most common
diseases of perinatal distress, but the current research of high-quality prevention and
treatment of postpartum depression is still very lack. The study suggests that the risk of
postpartum depression in cesarean delivery is significantly higher than that in vaginal
delivery. Therefore, postpartum depression in cesarean delivery may require more attention
and treatment.Tramadol is a non-opioid central analgesic that relieves common to severe pain,
and tramadol has an inhibitory effect on norepinephrine and serotonin systems and has the
potential to reduce depression and anxiety. Therefore, for the analgesic demand and
antidepressant demand for maternal who undergoing cesarean section, tramadol may be an
optimized and effective analgesic for the prevention and treatment of postpartum depression.