Effect of Transversus Abdominis Plane Block With Compound Lidocaine and Esketamine on Pain After Surgery

• Status: Not yet recruiting
• Trial end date: 2022-06-15
• Target enrollment: 0
• Participant gender: All

Summary

Purpose:

To explore effects of ultrasound-guided transversus abdominis plane block with compound lidocaine and esketamine on postoperative pain after colorectal cancer surgery.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Tianjin Medical University General Hospital
• Treatments: Esketamine; Lidocaine; Ropivacaine

Criteria

Inclusion Criteria:

1. Subject is scheduled to undergo colorectal cancer surgery under general anesthesia

2. Subject's American Society of Anesthesiologists physical status is I-II.

3. The subject's parent/legally authorized guardian has given written informed consent to participate.

Exclusion Criteria:

1. Subject has a diagnosis of bronchial asthma, coronary heart disease, severe hypertension, renal failure or liver failure.

2. Subject has a diagnosis of Insulin dependent diabetes.

3. Subject is allergy and contraindication to local anesthetics or any components of local anesthetics.

4. Subject has a history of chronic pain, a history of alcohol or opioid abuse, pre- existing therapy with opioids, intake of any analgesic drug within 48 hours before surgery.

5. Subject has any contraindication for the use of patient-controlled analgesia (PCA).

6. Subject is pregnant or breast-feeding.

7. Subject is obese (body mass index >30kg/m^2).

8. Subject is incapacity to comprehend pain assessment and cognitive assessment.