Effect of Ulinastatin on the Action of NDMRs (Rocuronium / Cisatracurium)

• Status: Not yet recruiting
• Trial end date: 2023-06-25
• Target enrollment: 0
• Participant gender: All

Summary

The aim of this research was to determine the influence of ulinastatin on nondepolarising muscle relaxants Rocuronium and Cisatracurium.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Huazhong University of Science and Technology
• Treatments: Urinastatin

Criteria

Inclusion Criteria:

1. Patients undergo elective pancreaticoduodenectomy surgery

2. Age ranging from 25 to 60 years，body mass index (BMI)18-24kg/m2, American Society of Anesthesiologists (ASA) grades 1 or 2.

3. Receive general anesthesia and muscle relaxants intraoperatively.

Exclusion Criteria:

1. patients ASA class 3 and above

2. Severe cardiac or respiratory diseases, liver or kidney disease

3. Pregnant women.

4. Patients with neurological dysfunction including myasthenia gravis, epilepsy or psychiatric disorders

5. Patients on any premedications including antisialagogues .

6. Patients on drugs known to interfere with neuromuscular transmission including but not exclusive to anticonvulsants, calcium channel blockers, β-blockers, corticosteroids, diuretics and antibiotics of the aminoglycoside group

7. Patients known allergy to propofol and sufentanil or remifentanil,

8. emergency operations.

9. Patients judged by the investigator to be unsuitable for participation in this study