Effect of Ultra-low Dose Naloxone During Supraclavicular Brachial Plexus Block on Post-operative Opioi
Status:
Completed
Trial end date:
2018-04-25
Target enrollment:
Participant gender:
Summary
Effective post-operative pain control can reduce patient morbidity and affect the patient
outcome. Brachial plexus block is one of them, a popular and widely employed regional nerve
block technique for perioperative anesthesia and analgesia for surgery of the upper
extremity.
Different drugs have been used as adjuvants with local anesthetics in brachial plexus block
to achieve quick, dense and prolonged block like Morphine, Pethidine, Clonidine,
Dexmedetomidine.
Naloxone is opioid antagonists which could selectively block the excitatory effects of
opioids. it release endorphins and also displace endorphins from receptor site .it also
reduce the opioid induced side effects, such as vomiting, nausea, pruritus, and respiratory
depression.