Effect of Ultra-low Dose Naloxone During Supraclavicular Brachial Plexus Block on Post-operative Opioi

• Status: Completed
• Trial end date: 2018-04-25
• Target enrollment: 0
• Participant gender: All

Summary

Effective post-operative pain control can reduce patient morbidity and affect the patient outcome. Brachial plexus block is one of them, a popular and widely employed regional nerve block technique for perioperative anesthesia and analgesia for surgery of the upper extremity.

Different drugs have been used as adjuvants with local anesthetics in brachial plexus block to achieve quick, dense and prolonged block like Morphine, Pethidine, Clonidine, Dexmedetomidine.

Naloxone is opioid antagonists which could selectively block the excitatory effects of opioids. it release endorphins and also displace endorphins from receptor site .it also reduce the opioid induced side effects, such as vomiting, nausea, pruritus, and respiratory depression.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Mansoura University
• Treatments: Bupivacaine; Naloxone

Criteria

Inclusion Criteria:

• American Society of Anesthesiology (ASA) physical state class Ι and II

• Elective upper limb orthopedic surgery (hand, forearm and elbow)

• Duration of surgery ≤180 min

• BMI ≤30 kg/m2

Exclusion Criteria:

• History of allergy to the drug of the study.

• Coagulation disorders

• Infection at the puncture site.

• Pregnancy

• Opioid abuse.

• Abuse of tranquilizers