Effect of Uridine on GABA and High Energy Phosphate Levels in Healthy Volunteers
Status:
Completed
Trial end date:
2008-08-01
Target enrollment:
Participant gender:
Summary
On the dual basis of findings indicating GABA increases following acute and eight week
SSRI/dopamine agonist administration and those indicating GABA-ergic effects following 14 day
pyrimidine administration, the purpose of this study is to assess our following hypotheses:
1. Relative to placebo, an oral dose of 1g of uridine BID for seven days will increase
brain GABA levels in a sample of healthy, unmedicated adult males;
2. Relative to placebo, an oral dose of 1g of uridine BID for seven days will increase NTP
levels in a sample of healthy, unmedicated adult males; and
3. Brain GABA levels will be directly correlated to high energy phosphate levels in this
sample of healthy, unmedicated adult males.