Effect of Urinary Alkalinization on Urine Uric Acid Precipitation and Crystallization in Adults With Type 1 Diabetes

• Status: Completed
• Trial end date: 2017-08-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine whether alkalinization of urine uric acid by 2 doses of sodium bicarbonate (1950mg) over 24-hours reduces precipitation and crystallization of urine uric acid over in adults with type 1 diabetes.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Colorado Denver School of Medicine Barbara Davis Center
• Treatments: Uric Acid

Criteria

Inclusion Criteria:

• Adults (aged 18-45 years) with type 1 diabetes

• Participants must be able to be fasting prior to study visit and give informed consent.

Exclusion Criteria:

• Non-type 1 diabetes

• History of eGFR <60 ml/min/1.73m2 or microalbuminuria or greater

• History of hypocalcemia or at risk of hypocalcemia

• Taking allopurinol or uric acid altering medications

• Ketogenic diet

• Ketonuria

• Taking phosphorus binders (e.g. sevelamer)

• Pregnant or breastfeeding

• Taking the following medications which may interact with sodium bicarbonate (e.g. phentermine, pseudoephedrine, antifungal medication, cephalosporin antibiotics [e.g. Keflex], tetracycline antibiotics [e.g. doxycycline], steroids or lithium)

• Taking SGLT-2 inhibitors

• Taking blood pressure medications