Effect of Urine-guided Hydration on Acute Kidney Injury After CRS-HIPEC

• Status: Recruiting
• Trial end date: 2025-01-01
• Target enrollment: 0
• Participant gender: All

Summary

Acute renal injury (AKI) is a common complication after cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy (CRS-HIPEC), and is associated with worse outcomes. Available evidences show that maintaining intraoperative urine output ≥ 200 ml/h by fluid and furosemide administration may reduce the incidence of AKI in patients undergoing cardiopulmonary bypass. The investigators hypothesize that, for patients undergoing CRS-HIPEC, intraoperative urine-volume guided hydration may also reduce the incidence of postoperative AKI.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Peking University First Hospital
• Collaborator: Aerospace Center Hospital
• Treatments: Furosemide

Criteria

Inclusion Criteria:

• Age ≥18 years;

• Diagnosed as pseudomyxoma peritonei, scheduled for cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy under general anesthesia;

• At least 14 days since the last treatment of chemotherapy, radiotherapy, or immunotherapy;

• Consent to participate in this study.

Exclusion Criteria:

• Persistent preoperative atrial fibrillation, or new-onset cardiovascular event (acute coronary syndrome, stroke, or congestive heart failure) in the past 3 months;

• Requirement of vasopressors to maintain blood pressure before surgery;

• Known furosemide hypersensitivity;

• Chronic kidney disease stage 5 or requirement of renal replacement therapy;

• Other conditions that are considered unsuitable for the study participation.