Effect of Using Diclofenac Sodium Versus Calcium Hydroxide as Intracanal Medication on the Intensity of Postoperative Pain and Bacterial Load Reduction in Patients With Necrotic Pulp: A Randomized Clinical Trial

• Status: Not yet recruiting
• Trial end date: 2024-08-01
• Target enrollment: 0
• Participant gender: All

Summary

the aim of this study is to compare the effect of using Diclofenac Sodium Versus Calcium Hydroxide as Intracanal medication on intensity of postoperative pain, bacterial load reduction after root canal preparation and periapical matrix metalloproteinase 9 level (MMP-9) post-instrumentation and pre-obturation in teeth with necrotic pulp

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Cairo University
• Treatments: Diclofenac

Criteria

Inclusion Criteria:

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Inclusion criteria:

• Patients who are free from any physical or mental handicapping condition with no underlying systemic disease.

• Age between 18-50 years.

• Males & Females.

• Mandibular single rooted permanent premolar teeth:

• Diagnosed clinically with pulp necrosis.

• Absence of spontaneous pain.

• Positive pain on percussion denoting apical periodontitis.

• Slight widening in the periodontal membrane space or with periapical radiolucency not exceeding 2*2 mm radiographically.

• Patients' acceptance to participate in the trial.

• Patients who can understand pain scale and can sign the informed consent

Exclusion Criteria:

• Medically compromised patients

• Pregnant women.

• If analgesics or antibiotics have been administrated by the patient during the past 24 hours preoperatively.

• Patients reporting bruxism or clenching.

• Teeth that show association with acute periapical abscess and swelling.

• Greater than grade I mobility or pocket depth greater than 5mm.

• Non-restorable teeth

• Teeth with vital pulp.

• Immature teeth.

• Radiographic evidence of external or internal root resorption vertical root fracture, perforation, calcification.