Effect of Valdecoxib Pretreatment on Pain and Secondary Hyperalgesia in Healthy Volunteers
Status:
Completed
Trial end date:
2006-04-01
Target enrollment:
Participant gender:
Summary
Tis study was designed to test the hypothesis that pretreatment with valdecoxib, prior to
injury could reduce or prevent the development of secondary hyperalgesia around the area of
primary injury. A heat/capsaicin model of induced hyperalgesia was tested in healthy
volunteers in a randomized, double blind, cross-over trial of a single dose of 40 mg
vadecoxib versus control. Subjects rated pain intesnsity and unpleasantness following heat
stimulation of the forearm, the area of hyperalgesia was also mapped over the course of the
experiment.