Effect of Varying Testosterone Levels on Insulin Sensitivity in Normal and IHH Men

• Status: Completed
• Trial end date: 2008-06-01
• Target enrollment: 0
• Participant gender: Male

Summary

Type 2 diabetes is one of the most common metabolic disorders in the U.S, estimated to affect 16 million Americans. Established risk factors for this disease include obesity, increased waist/hip ratio, high insulin levels in the blood, and insulin resistance. Testosterone may play a role in developing or preventing diabetes, but we do not yet know for sure. The purpose of this research study is to determine if changing testosterone levels in men will result in changes in insulin sensitivity. Information learned form this research study may have important public health implications and may point to new strategies for treating or preventing diabetes.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
• Collaborator: American Diabetes Association
• Treatments: Acyline; Insulin; Methyltestosterone; Testosterone; Testosterone 17 beta-cypionate; Testosterone enanthate; Testosterone undecanoate

Criteria

Inclusion Criteria:

Healthy men:

Good general health,

• Normotensive,

• Normal testosterone levels,

• No medications known to influence glucose homeostasis or testosterone levels

IHH men:

• Good general health;

• Normal thyroid, adrenal, and GH axes;

• Normal prolactin levels;

• No abnormalities on imaging of the hypothalamic-pituitary region;

• No medications known to influence glucose homeostasis;

• Must have been off hormone therapy for a suitable washout period depending on the type of prior androgen replacement