Effect of Vitamin D After Application With Valchlor

• Status: Unknown status
• Trial end date: 2018-12-15
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this research study is to evaluate the effects of an oral Vitamin D on the body's immune system.

An interest has been growing because studies have shown that Vitamin D may reduce inflammation and harmful effects in the body, however, the best dose for Vitamin D is still unknown.

Inflammation is the body's physical response to infection, injury, or long term disease. Pain, redness, heat, and sometimes loss of function are all signs of inflammation in the body. This study will look at product use, testing skin irritation in healthy volunteers and seeing how Vitamin D may help stop or reduce inflammation and skin irritation, which could one day help doctors prescribe Vitamin D to patients with long term disease to relieve their symptoms.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Case Comprehensive Cancer Center; University Hospitals Cleveland Medical Center
• Collaborators: National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS); National Institutes of Health (NIH)
• Treatments: Cholecalciferol; Ergocalciferols; Mechlorethamine; Vitamin D; Vitamins

Criteria

Inclusion Criteria:

• Must be in general good health

• Fitzpatrick Skin Type I-VI

• Able to list all current medications and medical conditions

• Capable of giving informed consent

Exclusion Criteria:

• Women who are pregnant, nursing, or who may become pregnant in the next 3 months

• Participants taking illegal drugs

• Currently taking ketoconazole, colestipol, cholestyramine, phenobarbitol, phenytoin, or mineral oil

• Currently consuming 800IU or more of vitamin D a day

• Subjects whose BMI are > 40