Effect of Vitamin D Oral Supplementation in Poly Csytic Ovarian Women Resistant to Clomiphene Citrate

• Status: Not yet recruiting
• Trial end date: 2021-12-01
• Target enrollment: 0
• Participant gender: Female

Summary

effect of vitamin D oral supplementation in poly csytic ovarian women resistant to clomiphene citrate

• Phase: Phase 1/Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: rana alaaeldin aly ibrahim nasr
• Collaborator: Ain Shams University
• Treatments: Vitamin D

Criteria

Inclusion Criteria:

• Age: 18-40 years 2- Polycystic ovarian syndrome diagnosis made according to ESHRE/ASRM criteria.

1. Polycystic ovaries (either 12 or more follicles or increased ovarian volume [> 10 cm3

2. Oligo-ovulation or anovulation

3. Clinical and/or biochemical signs of hyperandrogenism (Azziz, 2006). 3- PCOS infertile women resistant to CC for 3 cycles. clomiphene citrate resistance means failure to ovulate with 3 months use of clomid at 150 mg/day for 5 days

Exclusion Criteria:

• Causes of infertility other than PCOS.

1. Male factor.(normal semen analysis)

2. Other factors e.g. endometriosis

3. Tubal factor. (normal hysterosalpingography)

4. Premature ovarian failure: Day 3 FSH > 14 mlu/ml or antimullerian hormone <1 ng/ml.

5. Normal ultrasound except for criteria of PCO

• Causes of anovulation other than PCOS.

• Patients with hyperprolactinemia

• Patients with thyroid dysfunction.

• Current or in last six months use of vit D treatment.