Effect of Vitamin D Replacement in Patients With Urolithiasis
Status:
Terminated
Trial end date:
2016-05-01
Target enrollment:
Participant gender:
Summary
When Vitamin D replacement is initiated in patients with history of urolithiasis, there will
be higher incidence of hypercalciuria but with careful follow-up of these patients,
hypercalciuria could be appropriately managed with thiazide diuretics so that the risk of
newly diagnosed renal stones will be equivalent to control groups without Vitamin D
replacements.the purpose of the study is to determine the effect of vitamin D replacement in
patients with previous history of urolithiasis presenting to a tertiary stone clinic in terms
of changes in 24-hour urine collection parameters and to evaluate the lithogenic effect of
vitamin D replacement in terms of development of urolithiasis. Eighty-six eligible patients
will be included in terms of having suboptimal vitamin D with history of calcareous
urolithiasis and urinary calcium excretion <7.5 mmol/day. Patients will be randomly divided
into 2 equal groups depending on whether they will receive vitamin D replacement with
follow-up at 3, 6, 12, & 24 months.
Details
Lead Sponsor:
McGill University Health Center McGill University Health Centre/Research Institute of the McGill University Health Centre
Treatments:
Cholecalciferol Ergocalciferols Vitamin D Vitamins