Effect of Vitamin D3 Supplementation in Pregnancy on Risk of Pre-eclampsia

• Status: Completed
• Trial end date: 2015-12-31
• Target enrollment: 0
• Participant gender: Female

Summary

Vitamin D deficient pregnant ladies were selected and randomized into 2 groups for routine daily dose of multivitamin (400IU vitamin D3) versus maximum safest treatment daily dose (4000IU vitamin D3). Participants were assessed and compared for number of pre-eclampsia cases.

• Phase: Phase 1/Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: King Fahad Medical City
• Treatments: Cholecalciferol; Ergocalciferols; Vitamin D; Vitamins

Criteria

Inclusion Criteria:

• Confirmed singleton pregnancy of less than 13 completed weeks of gestation at the time of consent.

• Planned to receive antenatal care in King Fahad Medical City antenatal clinic.

• The ability to provide written informed consent at the first visit.

• Low risk pregnancy; and Serum vitamin D3 levels less than < 25nmol/L.

Exclusion Criteria:

• Mothers with pregnancy with abnormal foetus.

• Previous history of hypertension, pre-eclampsia, recurrent miscarriages.

• Chronic kidney disease, chronic liver disease, and malignancy.