Effect of Weight and Insulin Sensitivity on Reproductive Function in PCOS
Status:
Completed
Trial end date:
2016-12-01
Target enrollment:
Participant gender:
Summary
Polycystic ovary syndrome (PCOS) is the most common reproductive disorder in women of
reproductive age and despite decades of research the etiology the disorder is not known. The
characteristic hyperandrogenism and anovulation is associated with abnormal neuroendocrine
function and insulin resistance. Obesity is a common correlated phenotype of Polycystic ovary
syndrome and weight gain worsens the reproductive and metabolic complications. Currently
there is no evidence-based treatment plan for infertility in Polycystic ovary syndrome; yet
weight loss by dietary restriction and regular exercise are strongly advocated. Weight loss
and increased insulin sensitivity appear to drive improvements in reproductive outcomes in
women with Polycystic ovary syndrome; however, the mechanism connecting these changes with
the reproductive axis is not fully understood.
Phase:
Phase 3
Details
Lead Sponsor:
Pennington Biomedical Research Center
Collaborator:
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)