Effect of Zanthoxylum Nitidum Tincture for Paronychia Caused by Afatinib

• Status: Recruiting
• Trial end date: 2021-12-01
• Target enrollment: 0
• Participant gender: All

Summary

This is a randomized control trial evaluating the efficacy of zanthoxylum nitidum tincture on preventing progression of paronychia caused by afatinib from grade 1 to grade 2/3. Enrolled participates will randomly receive original treatment or original treatment plus zanthoxylum nitidum tincture immersion of the sick nail(s).

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Guangzhou University of Traditional Chinese Medicine
• Treatments: Afatinib; Tetracycline

Criteria

Inclusion Criteria:

1. Pathologically or cytologically confirmed non-small cell lung cancer；

2. Undergoing treatment with afatinib；

3. With grade 1 paronychia；

4. Age between 18 to 80 years old；

5. Estimated life expectancy of more than months；

6. With the written informed consent.

Exclusion Criteria:

1. Paronychia before afatinib treatment;

2. Grade 2 or severer paronychia;

3. Stop using afatinib or with reduced dose of afatinib;

4. Currently diagnosed with severe encephalopathy or psychiatric disorders affecting patients ability of self expression.

5. Has other legal, medical or ethical reasons that patients are not appropriate for clinical study.