Effect of a Bolus of Clonidine Systemically Administered on the Excitability of the Spinal Motoneurons of the Lower Extremity

• Status: Recruiting
• Trial end date: 2022-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to assess the effect of IV clonidine administration on lower limb spinal motoneuron excitability during standardized total intravenous anesthesia (propofol and remifentanil).

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Queen Fabiola Children's University Hospital
• Collaborator: Brugmann University Hospital
• Treatments: Anesthetics; Clonidine

Criteria

Inclusion Criteria:

1. Patients aged 6 to 18 years at time of hospital admission

2. Planned hospital admission for tympanoplasty

3. Informed Consent signed by both parents

Exclusion Criteria:

1. Known hypersensitivity to clonidine or to any component of the Catapressan

2. Patient treated with alpha2 agonists

3. Surgical emergency

4. Patient treated with antipsychotic drugs(butyrophenone, phenothiazine, tricyclic antidepressant)

5. Abnormal heart rhythms

6. Neuromuscular disease

7. Renal impairment

8. Patient treated with methylphenidate

9. Pregnant or breastfeeding woman