Effect of a Continuous Infusion of Esmolol on Stroke Volume in Patients With Hyperdynamic Vasoplegic Septic Shock
Status:
Withdrawn
Trial end date:
2017-08-01
Target enrollment:
Participant gender:
Summary
The main objective of this study is to evaluate the effectiveness of the administration of a
short acting beta-blocker in terms of effective increase in stroke volume (at least 15%)
after 4 hours initiation of therapy in septic shock in patients with a hyperkinetic profile
after 12-24 hours of care.
This research seeks to demonstrate that the proportion of patients with an increase in the
systolic ejection superior or equal to 15% (relative to baseline) at four hours is different
between the two arms of the study: (1) an experimental arm where patients receive an esmolol
infusion according to a predetermined procedure and (2) a control arm where patients receive
a saline infusion according to a predetermined procedure.