Effect of a GnRH Injection on Ghrelin Concentrations in Girls With Suspected Premature Puberty

• Status: Completed
• Trial end date: 2018-09-01
• Target enrollment: 0
• Participant gender: Female

Summary

The purposes of the study is to investigate whether circulating levels of ghrelin decreases after an iv injection of GnRH in girls with suspected central premature puberty and to investigate the effects of different post sampling handling on the preservation of acylated ghrelin.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Region Örebro County
• Collaborator: Uppsala-Örebro Regional Research Council
• Treatments: Hormones

Criteria

Inclusion Criteria:

• Female gender.

• Clinical suspicion of central precocious puberty.

• A GnRH stimulation test is to be performed to make appropriate diagnosis.

Exclusion Criteria:

• Age < 1 year.

• Weight < 10 kg.

• Untreated hypo- or hyperthyroidism.

• Diabetes of any kind.

• BMI > 3 z-score.

• Growth hormone treatment.

• Syndrome or suspected syndrome.

• Tumour or congenital malformation of the hypothalamus or the pituitary gland. (Neuroradiology does not have to be performed only because of the study.)

• On going ulcus ventriculi or the patient has gone through surgery that removed part of the ventricle or changed it markedly in any other way.