Effect of a Proton Pump Inhibitor on Gleevec® in Healthy Volunteers
Status:
Completed
Trial end date:
2009-08-01
Target enrollment:
Participant gender:
Summary
This is a research study that will investigate the effects of proton pump inhibitors (often
used to treat stomach upset) on Gleevec® (a drug that is FDA-approved to treat some types of
cancer) in healthy volunteers. Twelve healthy volunteers (six men and six women) will be
recruited to complete the study. This research study will compare Gleevec® in the body when
taken with and without proton pump inhibitors (PPI). Each volunteer will receive a 400 mg
pill of Gleevec® on two occasions. On one occasion they will take the dose of Gleevec® alone
(without PPI). On another occasion, they will take the Gleevec® after taking 40 mg of PPI
daily by mouth for six days. Several blood samples will be drawn to measure the
concentrations of Gleevec® and its breakdown products in the blood, with and without the
influence of PPI.