Effect of the Adjunctive IVB Before PRP

• Status: Completed
• Trial end date: 2013-08-01
• Target enrollment: 0
• Participant gender: All

Summary

This study is to investigate the effect of adjunctive intravitreal bevacizumab (IVB) before panretinal photocoagulation (PRP) compared with only PRP on central macular thickness and retinal nerve fiber layer thickness in patients with severe diabetic retinopathy without macular edema.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Kyungpook National University; Kyungpook National University Hospital
• Treatments: Bevacizumab

Criteria

Inclusion Criteria:

• patients with severe NPDR or early PDR without macular edema

• best-corrected visual acuity (BCVA) of 20/25 or better

• patients who were followed up for at least 6 months after the first PRP.

Exclusion Criteria:

• patients with retinal or choroidal diseases except diabetic retinopathy

• contraindications to fluorescein angiography (FA) or bevacizumab

• patients who had previous treatments including anti-angiogenic medications and laser photocoagulation

• patients with previous vitrectomy

• patients with uncontrolled hypertension, a recent myocardial infarction or cerebral vascular accidents.