Effect of the Aquaretic Tolvaptan on Nitric Oxide System (TORA)

• Status: Completed
• Trial end date: 2014-03-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to investigate the effect of tolvaptan on renal water, sodium and potassium excretion, plasma concentration of vasoactive hormones,central blood pressure, pulse wave velocity (PWV) and augmentation index, basal and during inhibition of nitric oxide synthesis in healthy subjects.

• Phase: Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Regional Hospital Holstebro
• Treatments: Nitric Oxide; Tolvaptan

Criteria

Inclusion Criteria:

• Men and women, age 18-40 years

• Body Mass Index (BMI) 18,5-30 kg/m2

Exclusion Criteria:

• Anamnestic or clinical signs of heart, lung, lever, kidney and brain disease

• Neoplastic disease

• Drug abuse

• Alcohol abuse

• Medical treatment except peroral anticontraceptive

• Pregnancy

• Smoking

• Abnormal blood and urine sample

• Abnormal ECG

• Blood donation within a month before examination

• Arterial hypertension (>140 mmHg systolic and/or 90 mmHg diastolic)