Effect of the Direct Renin Inhibitor Aliskiren on Endothelial Function and Arterial Stiffness in Diabetic Subjects

• Status: Terminated
• Trial end date: 2012-01-01
• Target enrollment: 0
• Participant gender: All

Summary

The study will evaluate the effects of the direct renin inhibitor, aliskiren, on flow-mediated dilation of the brachial artery and on central aortic pressure in diabetic patients with pre-hypertension or Stage 1 hypertension.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Alabama at Birmingham
• Collaborator: Novartis

Criteria

Inclusion Criteria:

• Type 2 diabetes

• prehypertension or Stage 1 hypertension

Exclusion Criteria:

• Type 1 diabetes

• Stage 2 hypertension

• CKD

• recent MI, revascularization, CVA or TIA