Effect of the Motilin Receptor Agonist, Erythromycin, on Hunger and Food Intake; Study of Role of Cholinergic Pathways

• Status: Completed
• Trial end date: 2014-08-01
• Target enrollment: 0
• Participant gender: All

Summary

In this study, the investigators will evaluate if the food intake associated with the infusion of erythromycin is caused by the phase 3 contractions or by another yet unknown effect of erythromycin. To obtain this the investigators will use atropine, a muscarinic receptor antagonist, to inhibit the formation of contractions induced by a low dose of erythromycin

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Universitaire Ziekenhuizen Leuven
• Treatments: Atropine; Erythromycin; Erythromycin Estolate; Erythromycin Ethylsuccinate; Erythromycin lactobionate; Erythromycin stearate

Criteria

Inclusion criteria:

• Female or male subjects aged 18 to 60

• Subject is capable and willing to give informed consent

• Female volunteers of child bearing potential must use oral, injected or implanted hormonal methods of contraception

Exclusion criteria:

• Female volunteer is pregnant or breastfeeding

• Gastrointestinal diseases, major abdominal surgery

• Major psychiatric illnesses

• Volunteers that use drugs affecting the gastrointestinal tract or the central nervous system

• Allergy for macrolide antibiotics

• Allergy for atropine

• Severe heartburn

• Enlarged prostate

• Blockage of urinary tract

• Acute closed-angle glaucoma

• Myasthenia gravies

• Severe heart disease

• Thyrotoxicosis

• Fever

• Liver problems

• High blood pressure or fast heart rate

• Lung disease