Effect of the SCL16A11 Risk Haplotype on Treatments to Prevent Type 2 Diabetes
Status:
COMPLETED
Trial end date:
2024-03-01
Target enrollment:
Participant gender:
Summary
The goal of this randomized clinical trial is to determine the impact of the risk haplotype on SLC16A11 on early therapeutic responses in treatments to prevent T2D in Mexican mestizos with prediabetes. The main question\[s\] it aims to answer are:
* Evaluate the effect of the risk haplotype on weigth loss \>3%
* Evualuate the differences in lipid profiles and glycemic parameters (fasting glucose, HbA1c).
Participants will be randomized into two groups: lifestyle intervention (LSI): hypocaloric diet, 25 kcal/kg of ideal weight, 45% of the total intake of carbohydrates, 30% lipids, and 25% protein sources + physical activity (\>150 min medium intensity per week), or LSI + MET (750 mg metformin twice a day).
Researchers will compare carriers and non carriers of the risk haplotype of SLC16A11 to see if there are diferent treatment responses.
Phase:
PHASE2
Details
Lead Sponsor:
Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran