Effect on Orencia (Abatacept) on the Apoptosis of T Cells, B Cells and APC Cells in Rheumatoid Arthritis

• Status: Withdrawn
• Trial end date: 2014-11-01
• Target enrollment: 0
• Participant gender: All

Summary

This proposal will test the hypothesis that Orencia affects apoptosis and apoptosis related genes/biomarkers in vivo in rheumatoid arthritis (RA) patients.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of California, Los Angeles
• Collaborator: Bristol-Myers Squibb
• Treatments: Abatacept

Criteria

Inclusion Criteria:

1. Over age 18

2. Meeting ACR Criteria 1987 for RA diagnosis

3. Naïve to treatment with abatacept

4. Must be able to understand information in the Informed Consent

Exclusion Criteria:

1. Pregnancy or breast feeding

2. Previous exposure to abatacept.

3. History of a concomitant autoimmune disease (eg. SLE, PsA etc.)

4. Patients with history of cancer