Effect(s) of Esketamine Combined With Pregabalin on Postsurgical Pain in Spinal Cord Neoplasms Patients

• Status: Not yet recruiting
• Trial end date: 2022-11-30
• Target enrollment: 0
• Participant gender: All

Summary

Postsurgical pain is now known to be one of the most common and difficult-to-treat complications of surgery. Persistent pain can significantly impair patients' quality of life, social functioning and contribute to excessive health care expenditures. It is worth noting that acute postoperative pain may play a vital role in central sensitization and up-regulation of pain receptors, factors implicated in the development of CPSP. Poorly perioperative pain management may increase the incidence of CPSP. According to previous studies, the incidence of postoperative pain among patients undergoing spinal surgery was nearly 40%. At the same time, perioperative pain management of patients undergoing spinal surgery has not been clearly. For the past few years, pregabalin and esketamine are becoming important roles in perioperative pain management, lots of studies have shown that these two analgesics might relieve postoperative pain. The aim of this study was to evaluate the analgesic effects of esketamine and pregabalin in combination after spinal cord neoplasms resection, so as to find a better way to help the patients undergoing spinal surgery keep away from the perioperative pain.

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Beijing Tiantan Hospital
• Treatments: Esketamine; Ketamine; Pregabalin

Criteria

Inclusion Criteria:

• Patient undergoing elective spinal cord neoplasms resection;

• Ages between 18 and 65 years old;

• American Society of Anaesthesiology (ASA) status I-III;

• Signed informed consent.

Exclusion Criteria:

• Previous adverse reaction to ketamine, s-ketamine or pregabalin;

• Patients with a diagnosed history of severe chronic pain;

• Patients with long-term analgesic treatment(gabapentin/opioids/ketamine);

• Patients with aphasia or inability to cooperate with the pain assessments;

• Known sever insufficiency of vitals(such as heart failure/renal dysfunction/hepatic failure);

• Patients with a diagnosed history of psychiatric disorder;

• Patients treated with gabapentin/pregabalin in the last three months;

• Drug abuse;

• Body mass index (BMI) > 35 kg/m2 ;

• Pregnancy or lactation.