Effect-site Concentration of Remifentanil for Smooth Induction With Desflurane
Status:
Completed
Trial end date:
2015-05-01
Target enrollment:
Participant gender:
Summary
Desflurane is a halogenated ether with low solubility, giving rapid induction and emergence
from anesthesia This character is suitable for Volatile Induction and Maintenance Anesthesia
(VIMA). But desflurane can cause airway irritation when it used as a sole induction agent to
adult or children, so there were many studies about reducing the airway reflex combined with
desflurane.
Remifentanil is a short acting opioid and is quickly hydrolyzed by nonspecific esterase in
the plasma and multiorgan. Several studies suggest the optimal dose of remifentanil for
reducing airway reflex or cardiovascular response for intubation combined with desflurane.
But these studies were under 1 Minimal Alveolar Concentration (MAC) of desflurane and this
point could be a limitation because desflurane concentration over 1 MAC increase airway
irritation significantly. This study this study was designed to determine a median effective
effect-site concentration (EC50) of remifentanil to prevent airway irritation during
desflurane anesthesia over 1 MAC.