Effective Dose of Remimazolam for Sedation in Patients Undergoing Lower Extremity Surgery Under Spinal Anesthesia
Status:
Recruiting
Trial end date:
2022-12-31
Target enrollment:
Participant gender:
Summary
Currently used drugs for monitored general anesthesia include propofol, midazolam, and
dexmedetomidine. Each drug has different advantages and disadvantages. Remimazolam causes a
relatively small decrease in blood pressure, and it has no injection pain. In addition,
remimazolam has a very short onset time, and even after the continuous infusion, the onset of
remimazolam is fast, and even after continuous injection, the effect disappeared very quickly
due to the short context-sensitive half time. and through continuous infusion, the patient's
depth of anesthesia can be maintained constant. In addition, the short duration of action and
the ability to quickly reverse the effect of flumazenil suggest that remimazolam can be used
effectively under general anesthesia as well as under general anesthesia. Remimazolam can be
used as a continuous infusion for general anesthesia. However, it has also been reported to
be used for sedation by continuous infusion or divided intravenous infusion. However, the
effective infusion dose of remimazolam for supervised general anesthesia without mechanical
ventilation has not been established.
In this study, the ED90 of the maintenance dose that maintain loss of consciousness in
patients when supervised general anesthesia is performed through continuous infusion of
remimazolam after spinal anesthesia is obtained.