Effectiveness Of High Dose Melatonin As Adjunctive Therapy For Dengue Fever With Warning Signs
Status:
Not yet recruiting
Trial end date:
2022-10-30
Target enrollment:
Participant gender:
Summary
Dengue Hemorrhagic Fever is a mosquito-borne viral disease endemic in the Philippines which
caused multiple epidemics. Most points to the activation of the complement system secondary
to humoral respond leading to cytokine release causing systemic inflammation. Melatonin, is a
hormone which has an a) anti-viral, b) immunomodulator, c) antioxidant, d) modulatory effect
on hematopoiesis and e) anti-inflammatory action.
This is a randomized control trial to determine the effectiveness of adjunctive melatonin
therapy among patients diagnosed with Dengue fever with Warning Signs. This would include
children aged 5 to 18 years old with no signs of hemmorhagic shock. They would be randomly
assigned into 2 groups. Baseline Complete blood count with platelet (CBCPC) will be
collected. Daily CBCPC will be collected and would be statistically analyze after the study.