Effectiveness Study of the Drug Tranexamic Acid to Reduce Post-surgery Blood Loss in Spinal Surgery
Status:
Completed
Trial end date:
2015-04-22
Target enrollment:
Participant gender:
Summary
Hypothesis: Topical application of Tranexamic acid into the surgical wound during spine
surgery will decrease the overall blood loss post-operatively. This reduction in blood loss
will reduce the need for transfusion. In addition it will also significantly reduce the cost
of the surgical procedure.
Specific Aim 1: The goal of this study is to quantitatively assess whether topical
application of tranexamic acid placed into the surgical wound during lumbar spine surgery
will decrease post-operative blood loss, thus lowering the need for blood transfusions. By
reducing the number of transfusions participants can avoid the well-known complications
associated with them. The investigators do not plan on measuring serum tranexamic acid
levels.
Several meta-analyses and level I studies have shown that intravenous (IV) administration of
tranexamic acid is effective in reducing postoperative blood loss and the need for
transfusion.