Effectiveness and Safety of Platelet Rich Plasma (PRP) on Persistent Olfactory Dysfunction Related to COVID-19
Status:
Completed
Trial end date:
2021-08-01
Target enrollment:
Participant gender:
Summary
Olfactory dysfunction (OD) is a well know symptom of coronavirus disease 2019 (COVID-19),
accounting for 48 to 85% of patients. In 1 to 10% of cases, patients develop a chronic
olfactory dysfunction (COD,) lasting more than 6 months. Recently, platelet-rich plasma (PRP)
was used in patients with non-COVID-19 COD and authors reported encouraging results. In the
present study, we investigated the usefulness and safety of PRP injection in 56 patients with
COVID-19 COD.
Our results showed that PRP in the olfactory cleft can increase the olfactory threshold one
month after the injection. Moreover, our results suggest that timing of treatment may be an
important factor and that PRP is a safe treatment because no adverse effects were reported
throughout the study