Effectiveness of Antipsychotic Combination With Psychosocial Intervention on Outcome of Patients With Schizophrenia

• Status: Completed
• Trial end date: 2007-12-01
• Target enrollment: 0
• Participant gender: All

Summary

Antipsychotic alone is limit to improve the overall outcome of schizophrenia and has a high discontinue rate.To solve these problems, we provide practical and available psychosocial intervention. We hypothesize that there will be significant difference in the overall effectiveness between antipsychotic and antipsychotic combination with psychosocial intervention.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Central South University
• Collaborators: Capital Medical University; Chongqing Metal Institute; Guangzhou Mental Hospital; Henan Mental Hospital; Hunan Mental Hospital; Jiangxi Mental Hospital; Nanjing Medical University; Shanghai Mental Health Center; Sichuan University
• Treatments: Antipsychotic Agents; Chlorpromazine; Clozapine; Olanzapine; Quetiapine Fumarate; Risperidone; Sulpiride

Criteria

Inclusion Criteria:

• Eligible patients were 16 to 50 years of age;

• had received a diagnosed of schizophrenia in accordance with criteria set out in the Diagnostic and Statistical Manual of Mental Disorders-fourth edition (DSM-IV);

• were confirmed to be clinically stable by the investigator (the total score ≤60 on the Positive and Negative Syndrome Scale [PANSS] or a decrease of fifty percent from acute period in the total score on PANSS)

• and taken maintenance treatment with any one of the following seven oral antipsychotics:

• chlorpromazine

• sulpiride clozapine

• risperidone

• olanzapine

• quetiapine

• aripiprazole

Exclusion Criteria:

• Patients were excluded if they had received a diagnosis of schizoaffective disorder, mental retardation, or other cognitive disorders;

• had a history of serious adverse reactions to the proposed treatment;

• were pregnant or breastfeeding; or had a serious and unstable medical condition.

• Patients were excluded if they were unable to provide informed consent