Effectiveness of Ascorbic Acid and Tocopherol for Depression in Elderly.
Status:
Completed
Trial end date:
2018-01-01
Target enrollment:
Participant gender:
Summary
The trial aims to treat depression. The incidence of major depression in the elderly accounts
for between 3.6 and 4.8% and increases to 8 to 37.4% when depressive disorders in general is
studied. Besides depression in the elderly presents with cognitive impairment, impaired
physical and social functioning, and predisposes to suicide. These are patients who often
have multiple conditions and be taking numerous psychopharmacological treatments which
hinders further treatment. The clinical trial will analyze the improvement in
neuropsychiatric symptoms through different instruments The Beck Depression Inventory (BDI),
State-Trait Anxiety Inventory (STAI), Life Events (AV), World Health Organization Disability
Assessment Schedule 2.0 (WHODAS 2.0), Wechsler Memory Scale (WMS-III), Mini mental state
examination (MMSE), Clinical Global Impression (CGI) and metabolic changes in the blood test
measurements; after 12 weeks of antioxidant (Ascorbic acid and Tocopherol) treatment or
placebo, and then after 24 weeks on active treatment with the antioxidant combination
(Ascorbic acid and Tocopherol).
Phase:
Phase 2
Details
Lead Sponsor:
Yolanda de Diego Otero
Treatments:
alpha-Tocopherol Ascorbic Acid Tocopherols Tocotrienols Vitamin E Vitamins