Effectiveness of Autologous Adipose-derived Stem Cells in the Treatment of Knee Cartilage Injury

• Status: Recruiting
• Trial end date: 2022-12-01
• Target enrollment: 0
• Participant gender: All

Summary

This study was aimed to evaluate the efficacy and safety of Autologous Adipose-derived Mesenchymal Stem Cell Gel combine with High tibial osteotomy therapy in the treatment of cartilage damage in the knee. Investigator believe that this method will enable patients to recover better knee function and more repair of knee cartilage.

• Phase: Phase 1/Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Qilu Hospital of Shandong University
• Treatments: Hyaluronic Acid

Criteria

Inclusion Criteria:

• Aged 18-65 years, male and female, patient can tolerate surgery;

• Clinical diagnosis of degenerative arthritis by Radiographic Criteria;

• Obviously extra-articular malformation;

• Good contralateral interventricular cartilage;

• Course of disease ≥ six months;

• There was no obvious abnormality in tumor marker detection,or patient was evaluated has not at the risk of cancer;

• Subjects who understand and sign the consent form for this study.

Exclusion Criteria:

• Acute joint injury;

• Patients with severe primary diseases, such as cardiovascular,cerebrovascular, liver, kidney and hematopoietic system, and psychosis;

• Cancer patients;

• Women who are pregnant or breast feeding,or allergic constitution patient;

• Positive serology for HIV-1 or HIV-2, Hepatitis B (HBsAg, Anti-Hepatitis C virus -Ab), Hepatitis C (Anti-hepatitis C virus -Ab) and syphilis;

• Receive other open surgery related to knee operation within 6 months;

• Participation in another clinical trial;

• Failing to comply with the inclusion criteria, unwilling to comply with the research approach, or incomplete data affecting the curative effect or safety judgment.